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Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins
10:24

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Published on: September 28, 2012

DDB2 decides cell fate following DNA damage

Tanya Stoyanova1, Nilotpal Roy, Dragana Kopanja

  • 1Department of Biochemistry and Molecular Genetics (M/C 669), Cancer Center, University of Illinois at Chicago, 900 South Ashland Avenue, Chicago, IL 60607, USA.

Proceedings of the National Academy of Sciences of the United States of America
|June 23, 2009
PubMed
Summary

Damaged-DNA binding protein 2 (DDB2) regulates cell fate after DNA damage. DDB2 deficiency prevents apoptosis, promoting cell cycle arrest by stabilizing p21(Waf1/Cip1).

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