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Related Concept Videos

Protein Networks

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

Protein Networks

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

Protein-protein Interfaces

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...

Protein-Protein Interfaces

Protein-Protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...

Endocrine Signaling

Endocrine Signaling

Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.

Endocrine Signaling

Endocrine Signaling

Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.

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Related Experiment Videos

The first draft of the endostatin interaction network.

Clément Faye¹, Emilie Chautard¹, Bjorn R Olsen²

¹Institut de Biologie et Chimie des Protéines, UMR 5086 CNRS, University Lyon 1, IFR 128 Biosciences Gerland Lyon Sud, 7 passage du Vercors, 69367 Lyon Cedex 07, France.

The Journal of Biological Chemistry

|June 23, 2009

Summary

Endostatin, a collagen fragment, interacts with new molecules like collagen and amyloid peptides. This reveals its complex network involved in controlling angiogenesis, tumor growth, and neurodegenerative diseases.

Related Experiment Videos

Area of Science:

Biochemistry
Molecular Biology
Cell Biology

Background:

Endostatin is a collagen XVIII fragment found in vascular basement membranes.
Its precise molecular mechanisms of action remain incompletely understood.
Endostatin binds to heparin/heparan sulfate and other proteins.

Purpose of the Study:

To identify novel binding partners of endostatin.
To gain further insights into endostatin's molecular mechanisms of action.

Main Methods:

Surface plasmon resonance (SPR) arrays were utilized to discover new endostatin interactions.

Main Results:

New endostatin partners identified include glycosaminoglycans (chondroitin, dermatan sulfate), matricellular proteins (thrombospondin-1, SPARC), collagens (I, IV, VI), amyloid peptide Abeta-(1-42), and transglutaminase-2.
The endostatin network involves extracellular proteins with EGF and EGF-like domains, capable of calcium binding.

Conclusions:

The endostatin network's functions are diverse, potentially regulating angiogenesis, tumor growth, neurogenesis, and neurodegenerative diseases.
The specific role of the endostatin network depends on trigger events and tissue-specific protein availability.