Related Experiment Video
Updated: Jun 22, 2026

Orthotopic Injection of Breast Cancer Cells into the Mice Mammary Fat Pad
Published on: January 20, 2019
Invasive carcinoma of the breast accompanied by coarse calcification
Kenichiro Tanaka1, Futoshi Akiyama, Noriko Nishikawa
1Department of Surgery, Shizuoka Saiseikai General Hospital, 1-1-1 Ojika, Suruga-ku, Shizuoka 422-8527, Japan. k154768@siz.saiseikai.or.jp
Objective:
We describe the case of a woman with a left breast mass. At mammography, the mass was shown to be irregular and accompanied by coarse calcification. Core needle biopsy revealed invasive carcinoma and a mastectomy was performed. Histopathology showed fibrosis with partial hyalinization eccentrically placed within the tumor with a large area of calcification at the core.
Conclusion:
Benign calcifications within a breast mass are not diagnostic of a benign process if the imaging characteristics of the mass are suspicious.
Related Concept Videos
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Cancer Cell Migration through Invadopodia
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...