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Recurrent diseases in the renal allograft
1Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville 32610-0224.
Journal of the American Society of Nephrology : JASN
|August 1, 1991
Summary
Recurrent diseases after renal transplant, primarily glomerulonephritis, are a growing concern. Certain native kidney diseases increase recurrence risk, but transplantation may be viable even for Fabry
Area of Science:
- Nephrology
- Transplantation immunology
Background:
- Recurrent diseases post-renal transplant are increasingly recognized, contributing to allograft failure.
- Recurrent glomerulonephritis is the most common cause of post-transplant disease.
- Specific glomerulonephritides like IgA nephropathy and FSGS have high recurrence rates.
Purpose of the Study:
- To review the incidence and risk factors for recurrent diseases after renal transplantation.
- To evaluate the viability of renal transplantation in patients with specific native kidney diseases, including Fabry's disease.
Main Methods:
- Literature review of studies on recurrent diseases in renal allografts.
- Analysis of recurrence rates based on native kidney disease and donor type.
- Examination of outcomes in renal transplant recipients with Fabry's disease.
Main Results:
- Recurrent diseases account for 2-4% of allograft failures, with glomerulonephritis being most frequent.
- Living-related transplants show increased recurrence, especially with prior FSGS, IgA nephropathy, or HUS.
- Renal transplantation is increasingly considered a viable option for Fabry's disease patients.
Conclusions:
- Understanding recurrence patterns is crucial for improving long-term graft survival.
- Careful patient selection and monitoring are essential for high-risk groups.
- Transplantation offers a viable treatment option for systemic diseases like Fabry's, despite previous contraindications.