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Related Concept Videos

Development of the Heart01:27

Development of the Heart

The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Location and Orientation of the Heart01:13

Location and Orientation of the Heart

The human heart, despite its modest size and weight, is an organ of remarkable strength and endurance. Roughly the size of a fist, the heart weighs between 250 and 350 grams and is nestled within the mediastinum, the medial cavity of the thorax. It extends obliquely for about 12 to 14 cm, resting on the superior surface of the diaphragm. The heart is positioned anterior to the vertebral column and posterior to the sternum, with two-thirds of its mass lying to the left of the midsternal line.
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...

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Pipeline for Multi-Scale Three-Dimensional Anatomic Study of the Human Heart
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Development of the Jackson Heart Study Coordinating Center.

Brenda W Campbell-Jenkins1, Clifton C Addison, Lavon Young

  • 1Jackson Heart Study, 350 West Woodrow Wilson Drive, Suite 701, Jackson, MS 39213 USA. brenda.w.campbell@jsums.edu

International Journal of Environmental Research and Public Health
|June 23, 2009
PubMed
Summary

The Jackson Heart Study Coordinating Center (JHSCC) was developed to support a major cardiovascular disease (CVD) study in African Americans. The JHSCC ensures data validity and facilitates research, improving CVD understanding and outcomes.

Keywords:
African AmericansCVDCoordinating CenterJackson Heart Study

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Area of Science:

  • Public Health
  • Cardiovascular Research
  • Epidemiology

Background:

  • Cardiovascular disease (CVD) poses a significant public health burden, disproportionately affecting African Americans.
  • Addressing CVD requires robust research infrastructure to understand risk factors and progression.

Purpose of the Study:

  • To detail the establishment and operational procedures of the Jackson Heart Study Coordinating Center (JHSCC).
  • To support the Jackson Heart Study (JHS), a population-based investigation of CVD risk factors in African Americans.

Main Methods:

  • Development of a dedicated coordinating center with specialized staff for statistical, data management, and administrative support.
  • Implementation of protocols to ensure data validity, quality control, participant safety, and regulatory compliance.
  • Facilitation of participant recruitment, retention, and effective communication across study centers and the community.

Main Results:

  • The JHSCC has successfully supported the JHS, ensuring the validity of findings through rigorous data management and statistical analysis.
  • Facilitated the preparation of scientific reports, manuscripts for publication, and presentations of study results.
  • The JHSCC has become a crucial mechanism driving the Jackson Heart Study's activities and success.

Conclusions:

  • The JHSCC is an effective research mechanism essential for the Jackson Heart Study's operations and scientific output.
  • The center's infrastructure and support are vital for advancing CVD research among African Americans.