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Updated: Jun 22, 2026

Pipeline for Multi-Scale Three-Dimensional Anatomic Study of the Human Heart
Published on: June 28, 2024
Development of the Jackson Heart Study Coordinating Center
Brenda W Campbell-Jenkins1, Clifton C Addison, Lavon Young
1Jackson Heart Study, 350 West Woodrow Wilson Drive, Suite 701, Jackson, MS 39213 USA. brenda.w.campbell@jsums.edu
Insights
The Jackson Heart Study Coordinating Center (JHSCC) was developed to support a major cardiovascular disease (CVD) study in African Americans. The JHSCC ensures data validity and facilitates research, improving CVD understanding and outcomes.
Area of Science:
- Public Health
- Cardiovascular Research
- Epidemiology
Background:
- Cardiovascular disease (CVD) poses a significant public health burden, disproportionately affecting African Americans.
- Addressing CVD requires robust research infrastructure to understand risk factors and progression.
Purpose of the Study:
- To detail the establishment and operational procedures of the Jackson Heart Study Coordinating Center (JHSCC).
- To support the Jackson Heart Study (JHS), a population-based investigation of CVD risk factors in African Americans.
Main Methods:
- Development of a dedicated coordinating center with specialized staff for statistical, data management, and administrative support.
- Implementation of protocols to ensure data validity, quality control, participant safety, and regulatory compliance.
- Facilitation of participant recruitment, retention, and effective communication across study centers and the community.
Main Results:
- The JHSCC has successfully supported the JHS, ensuring the validity of findings through rigorous data management and statistical analysis.
- Facilitated the preparation of scientific reports, manuscripts for publication, and presentations of study results.
- The JHSCC has become a crucial mechanism driving the Jackson Heart Study's activities and success.
Conclusions:
- The JHSCC is an effective research mechanism essential for the Jackson Heart Study's operations and scientific output.
- The center's infrastructure and support are vital for advancing CVD research among African Americans.
Abstract:
The public health burden caused by cardiovascular disease (CVD) continues to adversely affect individuals in terms of cost, life expectancy, medical, pharmaceutical and hospital care. This burden has been excessive in the case of African Americans. The objective of this paper is to chronicle the procedures and processes that were implemented in the development of the Jackson Heart Study Coordinating Center. The Jackson Heart Study (JHS) is a population-based investigation of traditional and emerging risk factors that predict progression to CVD among African Americans. In response to the struggle against CVD, the Jackson Heart Study has convened a professional, technical, and administrative staff with specific competence in the operation of a coordinating center to handle the wide variety of areas related to CVD studies. The Jackson Heart Study Coordinating Center (JHSCC) was created to assure validity of the JHS findings and provide the resources necessary to meet comprehensive statistical needs (planning, implementing and monitoring data analysis); data management (designing, implementing and managing data collection and quality control), and administrative support. The JHSCC began with a commitment to support study functions in order to increase participant recruitment, retention and safety, meet regulatory requirements, prepare progress reports, and facilitate effective communication with the community and between all JHS centers. The JHSCC facilitates the efforts of the JHS scientists through the development and implementation of the study protocol. The efforts of the JHSCC have resulted in the successful preparation of scientific reports and manuscripts for publication and presentation of study findings and results. In summary, the JHSCC has emerged as an effective research mechanism that serves as the driving force behind the Jackson Heart Study activities.
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