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Related Experiment Video

Updated: Jun 22, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
12:33

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

[Not Available].

Sandra K Al-Tarawneh1, Sompop Bencharit

  • 1Department of Prosthodontics, School of Dentistry, University of North Carolina, Chapel Hill, NC, USA.

The Open Dentistry Journal
|June 23, 2009
PubMed
Summary

Recent mass spectrometry advances enable human saliva proteomic analysis. Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF) offers a promising tool for disease monitoring and biomarker discovery.

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Area of Science:

  • Proteomics
  • Biochemistry
  • Analytical Chemistry

Background:

  • Human saliva is an easily accessible biofluid.
  • Saliva's proteomic complexity has historically limited its use in analysis.
  • Advancements in mass spectrometry are revolutionizing proteomic studies.

Purpose of the Study:

  • To review the evolution of human saliva proteomic analysis.
  • To highlight the potential of surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF) for salivary diagnostics.
  • To discuss SELDI-TOF's role in biomarker discovery and treatment monitoring.

Main Methods:

  • Review of proteomic analysis techniques for human saliva.
  • Focus on surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF).
Keywords:
ProteomicsSELDISELDI-TOFbiomarkerbiomarker discoverymass spectrometryprotein chips.protein expressionproteomic profiling

Related Experiment Videos

Last Updated: Jun 22, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
12:33

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

  • Comparison of SELDI-TOF with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF).

    • Main Results:

    • SELDI-TOF integrates mass spectrometry precision with protein array throughput.
    • This technology enhances the feasibility of high-throughput salivary proteomic analysis.
    • SELDI-TOF demonstrates significant promise for clinical applications.

    Conclusions:

    • SELDI-TOF represents a significant advancement in salivary proteomic analysis.
    • This technology facilitates novel biomarker discovery in saliva.
    • Salivary proteomic analysis using SELDI-TOF holds potential for disease monitoring and treatment assessment.