P53 Arg72Pro polymorphism in gastric cancer patients
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Published on: May 10, 2024
Lessileia Gomes de Souza1, Jacqueline Miranda de Lima, Ismael Dale Cotrim Guerreiro da Silva
1Oncology Group, Medicine Department, Universidade Federal de Sao Paulo (UNIFESP/EPM), São Paulo, Brazil. lessileia@gmail.com
Introduction:
Polymorphism in codon 72, exon 4 of p53 may alter apoptosis and cancer progression.
Patients And Methods:
P53 Arg72Pro genotype was assessed by PCR from 84 gastric cancer patients and 185 controls. The control group was comparable in sex, race, age, smoking, and alcohol intake to the cancer group.
Results And Discussion:
There was no difference among the frequency of the alleles or genotypes between the groups. P53 Pro/Pro was associated to a lower risk of metastatic disease (p = 0.02) but not to lymph nodes metastasis or worst prognosis. Arg/Arg or Arg/Pro genotype may be associated to metastatic disease.
