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Related Experiment Video

Updated: Jun 22, 2026

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
07:18

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

Published on: June 13, 2019

[Intracortical dedifferentiated chondrosarcoma].

K Thöm1, S Bontikous, M Engelhardt

  • 1Klinik für Unfall- und Wiederherstellungschirurgie, Orthopädische Chirurgie, Diakoniekrankenhaus Rotenburg (Wümme), Elise-Averdieck-Strasse 17, Rotenburg (Wümme). ch2sek1@diako-online.de

Der Unfallchirurg
|June 23, 2009
PubMed
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A rare intracortical chondrosarcoma was discovered in a patient with oropharyngeal cancer. Surgical resection and osteosynthesis were performed, highlighting the importance of differential diagnosis for bone tumors.

Area of Science:

  • Orthopedic Oncology
  • Bone Tumors
  • Malignant Mesenchymal Tumors

Background:

  • Chondrosarcoma is the second most common malignant bone tumor.
  • Accurate classification relies on clinical, radiological, and pathological evaluation.
  • Intracortical chondrosarcoma is a rare subtype, first described in 2003.

Observation:

  • A 59-year-old patient presented with oropharyngeal squamous cell carcinoma.
  • Staging revealed a highly malignant intracortical dedifferentiated chondrosarcoma in the distal femur.
  • Initial diagnosis considered bone metastasis from the oropharyngeal primary.

Findings:

  • The patient underwent marginal extralesional tumor resection.
  • Composite osteosynthesis was performed following tumor removal.

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The In ovo CAM-assay as a Xenograft Model for Sarcoma
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Last Updated: Jun 22, 2026

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
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Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

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The In ovo CAM-assay as a Xenograft Model for Sarcoma
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The In ovo CAM-assay as a Xenograft Model for Sarcoma

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  • Histopathological analysis confirmed intracortical dedifferentiated chondrosarcoma.

    • Implications:

    • This case underscores the necessity of comprehensive differential diagnosis in bone tumor staging.
    • Accurate diagnosis is critical for appropriate therapeutic strategies.
    • Management requires careful consideration of both primary bone tumors and metastatic disease.