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Synthesis of Hypervalent Iodonium Alkynyl Triflates for the Application of Generating Cyanocarbenes
Published on: September 8, 2013
Total synthesis of cyathin A(3) and cyathin B(2)
1Department of Chemistry, Wayne State University, Detroit, MI 48236, USA.
Angewandte Chemie (International Ed. in English)
|June 23, 2009
Abstract:
A stereoselective synthesis of cyathin A(3) and cyathin B(2) has been achieved by a Prins-type reaction of a cycloalkenyl cyclopropanol. Particularly noteworthy is the use of a spirocyclobutanone moiety as a convenient scaffold for an efficient ring-closing metathesis to stereoselectively construct a suitably functionalized seven-membered ring (see scheme).
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