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Related Concept Videos

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Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
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Related Experiment Video

Updated: Jun 22, 2026

Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution
09:59

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Published on: July 4, 2014

Imaging pharmaceutical tablets with optical coherence tomography.

Jakob M A Mauritz1, Richard S Morrisby, Roger S Hutton

  • 1Department of Chemical Engineering and Biotechnology, Cambridge University, Pembroke Street, Cambridge, UK. jmam2@cam.ac.uk

Journal of Pharmaceutical Sciences
|June 23, 2009
PubMed
Summary

Optical coherence tomography (OCT) offers a non-destructive method for analyzing pharmaceutical tablets and coatings. This technique provides detailed depth profiles, correlating strongly with tablet structure for quality control.

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Area of Science:

  • Pharmaceutical analysis
  • Optical imaging technologies
  • Materials characterization

Background:

  • Optical coherence tomography (OCT) is an emerging non-destructive optical technique.
  • OCT provides depth profiles of 3D objects by detecting refractive index variations.
  • It utilizes near-infrared (NIR) light, bridging NIR spectroscopy and Terahertz (THz) measurements.

Purpose of the Study:

  • To evaluate the potential of OCT for analyzing pharmaceutical tablets and coatings.
  • To assess OCT as a practical and reliable tool in pharmaceutical manufacturing.
  • To explore the correlation between OCT image contrast and tablet structure.

Main Methods:

  • Testing of various pharmaceutical tablets with diverse shapes, formulations, and coatings using OCT.
  • Analysis of contrast origins in OCT images.
  • Consideration of absorption and scattering effects at different NIR wavelengths.

Main Results:

  • OCT images showed strong correlation between contrast and expected tablet structures.
  • The technique demonstrated its capability to analyze different tablet types and coatings.
  • Absorption and scattering influences were evaluated for the employed wavelength ranges.

Conclusions:

  • OCT is a promising diagnostic tool for tablet and coating technologies.
  • Its high speed and ease of implementation make it suitable for in-line quality control.
  • OCT has a significant role to play in advancing pharmaceutical manufacturing processes.