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Sleep disordered breathing in children in a general population sample: prevalence and risk factors
Edward O Bixler1, Alexandros N Vgontzas, Hung-Mo Lin
1Sleep Research & Treatment Center, Department of Psychiatry, Penn State University College of Medicine, Hershey, PA 17033, USA. ebixler@hmc.psu.edu
Insights
Sleep disordered breathing (SDB) affects 1.2% of elementary school children. Key risk factors include obesity, nasal issues, and minority status, highlighting the role of metabolic factors.
Area of Science:
- Pediatric Sleep Medicine
- Respiratory Health in Children
- Public Health
Background:
- Sleep disordered breathing (SDB) is a growing concern in pediatric populations.
- Understanding the prevalence and risk factors in children is crucial for early intervention.
Purpose of the Study:
- To determine the prevalence of SDB in elementary school children using clinically meaningful criteria.
- To identify independent risk factors associated with SDB in this age group.
Main Methods:
- A two-phased strategy was employed, starting with parental questionnaires for a large sample (N=5,740).
- A subset of children (N=700) underwent overnight polysomnography in a university sleep laboratory.
- Comprehensive assessments included polysomnography, physical examinations, and specialized evaluations.
Main Results:
- The prevalence of moderate SDB (apnea-hypopnea index ≥ 5) was found to be 1.2%.
- Independent risk factors identified included nasal abnormalities, minority status, snoring, and increased waist circumference.
- Tonsil size was not found to be an independent risk factor for SDB.
Conclusions:
- A 1.2% prevalence of significant SDB was observed in the studied elementary school population.
- Waist circumference, nasal abnormalities, and minority status emerged as significant risk factors.
- The strong correlation between waist circumference, BMI, and SDB severity suggests metabolic factors are critical in pediatric SDB.
Study Objectives:
Assess the prevalence based on clinically meaningful criteria (i.e., blood pressure) and identify risk factors of sleep disordered breathing (SDB) in a representative sample of elementary school children.
Design:
A random sample of the local elementary school children (K-5) were assessed using a two-phased strategy. In phase I a brief questionnaire was completed by a parent of each child in local elementary schools (N = 5,740), with a response rate of 78.5%. In phase II, randomly selected children and their parent spent a night in our sleep laboratory (N = 700) with a response rate of 70.0%.
Setting:
University sleep laboratory.
Participants:
Children enrolled in local elementary schools.
Intervention:
None.
Measurement & Results:
Each child was assessed with a full polysomnogram and completed a history/physical examination including an electrocardiogram, otolaryngology examination, and pulmonary evaluation. The prevalence of moderate SDB (apnea-hypopnea index > or = 5) was 1.2%. The independent risk factors included nasal abnormalities and minority associated only with mild (1 < AHI < 5) SDB and snoring and waist circumference associated with all levels of SDB. Tonsil size, based on visual inspection, was not an independent risk factor.
Conclusion:
The prevalence of AHI > or = 5 was 1.2% in a representative sample of elementary school children. Risk factors for SDB included waist circumference, nasal abnormalities (e.g., chronic sinusitis/rhinitis), and minority. The strong linear relationship between waist circumference and BMI across all degrees of severity of SDB suggests that, as in adults, metabolic factors may be among the most important risk factors for SDB in children.
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