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Related Experiment Video

Updated: Jun 22, 2026

High-Throughput Capable Three-Dimensional Tissue Model for Quantification of Electroporation Thresholds
08:23

High-Throughput Capable Three-Dimensional Tissue Model for Quantification of Electroporation Thresholds

Published on: August 19, 2025

Electroporation advances in large animals.

Scott D Reed1, Shulin Li

  • 1Department of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA 70803, USA.

Current Gene Therapy
|June 24, 2009
PubMed
Summary
This summary is machine-generated.

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Electroporation gene therapy shows promise in large animals for non-viral treatments. This review highlights advancements in techniques and applications for cancer therapy, vaccination, and improving livestock health.

Area of Science:

  • Biomedical Engineering
  • Gene Therapy
  • Animal Models

Background:

  • Non-viral gene therapy is crucial for clinical applications.
  • In vivo electroporation is a leading non-viral gene delivery method.
  • Large animal models are essential for translational research.

Purpose of the Study:

  • To review novel aspects of in vivo electroporation in large animals.
  • To discuss improvements in electroporation delivery and vaccine development.
  • To explore evolving electroporation techniques and their applications.

Main Methods:

  • Review of current literature on electroporation-mediated gene therapy in large animals.
  • Summary of applications in cancer therapy, vaccination, and animal growth.

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Electroporation of Functional Bacterial Effectors into Mammalian Cells
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Electroporation of Functional Bacterial Effectors into Mammalian Cells

Published on: January 19, 2015

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Last Updated: Jun 22, 2026

High-Throughput Capable Three-Dimensional Tissue Model for Quantification of Electroporation Thresholds
08:23

High-Throughput Capable Three-Dimensional Tissue Model for Quantification of Electroporation Thresholds

Published on: August 19, 2025

Electroporation of Functional Bacterial Effectors into Mammalian Cells
08:39

Electroporation of Functional Bacterial Effectors into Mammalian Cells

Published on: January 19, 2015

  • Analysis of novel techniques like electron avalanche transfection and electrosonoporation.

    • Main Results:

    • Electroporation shows efficacy in treating cancer in humans and vaccination in non-human primates.
    • Applications in reversing cachexia in dogs and improving piglet survival and growth rates.
    • Development of enhanced delivery techniques and parameter optimization for increased transfection efficiency.

    Conclusions:

    • In vivo electroporation is a powerful tool for gene therapy and vaccine development in large animals.
    • Ongoing research focuses on refining techniques and overcoming current limitations.
    • Electroporation holds significant potential for future biomedical and veterinary applications.