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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Increased serum HMGB1 is related to the severity of coronary artery stenosis

Xiaorong Hu1, Hong Jiang, Qijun Bai

  • 1Department of Cardiology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang, Wuhan, 430060, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|June 24, 2009
PubMed

Insights

Serum high mobility group box 1 (HMGB1) levels correlate with coronary artery stenosis severity. Elevated HMGB1 is linked to more severe coronary artery disease (CAD), particularly in unstable angina (UA) and stable angina (SA) patients.

Area of Science:

  • Cardiovascular Medicine
  • Inflammation Biology
  • Biomarker Discovery

Background:

  • High mobility group box 1 (HMGB1) is recognized as a pro-inflammatory cytokine implicated in coronary artery disease (CAD).
  • Understanding the role of HMGB1 in CAD pathogenesis is crucial for developing targeted therapies.
  • This study explores the association between serum HMGB1 levels and the extent of coronary artery narrowing.

Purpose of the Study:

  • To investigate the relationship between serum HMGB1 concentrations and the severity of coronary artery stenosis in patients.
  • To determine if HMGB1 levels can serve as a predictive biomarker for CAD progression.

Main Methods:

  • Serum HMGB1 concentrations were quantified using enzyme-linked immunosorbent assay (ELISA).
  • Coronary angiography was performed on all participants to assess stenosis severity.
  • Patients were stratified into quartiles based on their serum HMGB1 levels.

Main Results:

  • Serum HMGB1 levels were significantly higher in patients with unstable angina (USAP) and stable angina (SAP) compared to controls.
  • Gensini scores, reflecting coronary artery stenosis severity, were significantly higher in the upper HMGB1 quartiles (II, III, and IV) compared to the lowest quartile (I).
  • A strong positive correlation was observed between angiographic Gensini score and serum HMGB1 levels (r=0.710, p<0.05), particularly in SAP patients (r=0.786, p<0.05).

Conclusions:

  • Serum HMGB1 levels increase with the severity of coronary artery stenosis in both SAP and USAP patients.
  • The association is particularly pronounced in SAP patients, suggesting HMGB1's significant role in atherosclerotic CAD.
  • Elevated serum HMGB1 may be a key factor in the pathogenesis of atherosclerotic coronary artery disease.
Abstract

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