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Plasma oxidized lipoprotein(a) and its immune complexes are present in newborns and children

Junjun Wang1, Dongmei Niu, Yang Meng

  • 1Department of Biochemistry, Jinling Hospital, Clinical School of Medicine, Nanjing University, 210002, Nanjing, PR China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|June 24, 2009
PubMed

Insights

Oxidized Lp(a) and Lp(a) immune complexes are present in newborns, indicating oxidized lipoproteins may initiate atherosclerosis. Levels rise rapidly after birth, correlating with cholesterol and Lp(a) levels.

Area of Science:

  • Cardiovascular Research
  • Lipid Metabolism
  • Pediatric Cardiology

Background:

  • Oxidized Lp(a) [ox-Lp(a)] is implicated in atherosclerosis more than native Lp(a).
  • Understanding ox-Lp(a) and Lp(a) immune complex [Lp(a)-IC] distribution in neonates and children is crucial.

Purpose of the Study:

  • To investigate plasma ox-Lp(a) and Lp(a)-IC levels in newborns and children.
  • To characterize the distribution and correlations of these markers in early life.

Main Methods:

  • Plasma ox-Lp(a) and Lp(a)-IC levels were quantified using ELISAs.
  • Analysis included 747 children and 30 cord blood samples.

Main Results:

  • Newborns had significantly lower Lp(a), ox-Lp(a), and Lp(a)-IC levels than children, with rapid postnatal increases.
  • Distributions were skewed towards lower values in children; no age-group differences were observed.
  • ox-Lp(a) positively correlated with total/LDL cholesterol, Lp(a), and Lp(a)-IC. Lp(a)-IC correlated with sex, total/LDL cholesterol, Lp(a), and ox-Lp(a).
  • Lp(a) and Lp(a)-IC explained 42% of ox-Lp(a) variation; ox-Lp(a) explained 30% of Lp(a)-IC variation.

Conclusions:

  • The presence of ox-Lp(a) and Lp(a)-IC in newborns and children suggests an early role for oxidized lipoproteins in atherogenesis.
  • These findings highlight the potential initiating role of oxidized lipoproteins in the atherosclerotic process from infancy.
Abstract

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