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Sweet syndrome after kidney transplantation
A J Osband1, D A Laskow, R A Mann
1Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA. adena.osband@rwjuh.edu
Transplantation Proceedings
|June 24, 2009
Summary
This is the first reported case of Sweet syndrome (acute febrile neutrophilic dermatosis) in a solid organ transplant recipient. The patient
Area of Science:
- Dermatology
- Nephrology
- Transplant Surgery
Background:
- Sweet syndrome, or acute febrile neutrophilic dermatosis, is a rare inflammatory condition.
- Established associations include malignancies, infections, and drug reactions.
- No prior reports linked Sweet syndrome to solid organ transplantation.
Observation:
- A 38-year-old male kidney transplant recipient developed recurrent fevers and widespread skin lesions.
- Symptoms appeared 2 months post-transplant, following a period of dialysis.
- Skin biopsy confirmed Sweet syndrome; cultures were negative.
Findings:
- The patient's lesions responded favorably to high-dose prednisone therapy.
- The case suggests a potential link between post-transplant immunosuppression and Sweet syndrome.
- This represents the first documented instance of Sweet syndrome in a solid organ transplant recipient.
Implications:
- Highlights a novel association between immunosuppression and Sweet syndrome in transplant patients.
- Suggests the need for heightened awareness of Sweet syndrome in solid organ transplant recipients presenting with characteristic lesions.
- May prompt further research into the immunomodulatory effects contributing to Sweet syndrome post-transplantation.
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