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Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment

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Published on: September 20, 2020

Thyroid stimulating hormone and prospective memory functioning in old age.

Asa Livner¹, Ake Wahlin, Lars Bäckman

¹Aging Research Center, Karolinska Institutet, Gävlegatan 16, S-113 30 Stockholm, Sweden. asa.livner@ki.se

Psychoneuroendocrinology

|June 24, 2009

Summary

Higher thyroid stimulating hormone (TSH) levels within the normal range may improve prospective memory (ProM) in older adults. This suggests TSH ranges for seniors may need adjustment for optimal cognitive function.

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Area of Science:

Gerontology
Neuroscience
Endocrinology

Background:

Thyroid function alterations are common in the elderly.
Subclinical thyroid variations can impact cognitive performance.
The relationship between thyroid stimulating hormone (TSH) and prospective memory (ProM) in older adults is not well understood.

Purpose of the Study:

To investigate the association between subclinical variations in thyroid functioning and prospective memory (ProM) performance in older adults.
To determine if thyroid stimulating hormone (TSH) levels within the normal range influence ProM.

Main Methods:

Study included 103 participants aged 75 and older, free from diagnosed thyroid disorders.
Serum levels of TSH and thyroxine (T4) were measured.
Participants had TSH and T4 levels within established normal ranges.

Main Results:

A non-linear association was found between TSH levels and ProM performance.
Participants with TSH levels in the highest quartile demonstrated significantly better ProM performance compared to other quartiles.
Thyroxine (T4) levels showed no significant relationship with ProM performance.

Conclusions:

Subclinical variations in TSH, even within normal ranges, can affect prospective memory in older adults.
The findings suggest that the upper limit of the normal TSH range may need to be reconsidered for the elderly population, particularly concerning cognitive function.
Higher TSH levels within the normal range appear beneficial for prospective memory in individuals aged 75 and above.