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Related Experiment Video

Updated: Jun 22, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
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High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

[Not Available].

Keitetsu Abe1, Kenji Kashiwagi

  • 1Department of Ophthalmology, Yamanashi Prefectural Central Hospital, Kofu, Yamanashi, Japan.

The Open Ophthalmology Journal
|June 24, 2009
PubMed
Summary

Adding brinzolamide to latanoprost significantly reduces intraocular pressure (IOP) fluctuations over 24 hours in glaucoma patients. This combination therapy offers a sustained IOP-lowering effect, improving glaucoma management.

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Area of Science:

  • Ophthalmology
  • Pharmacology

Background:

  • Glaucoma management often requires combination therapy to control intraocular pressure (IOP).
  • Diurnal IOP fluctuations are a significant risk factor for glaucoma progression.

Purpose of the Study:

  • To evaluate the effect of adding brinzolamide to latanoprost on diurnal IOP fluctuations.
  • To determine if brinzolamide provides additive IOP-lowering effects in patients already treated with latanoprost.

Main Methods:

  • Prospective study involving 11 patients with primary open-angle glaucoma.
  • IOP measurements taken over 24 hours before and after 4-8 weeks of twice-daily brinzolamide administration.
  • Patients were on latanoprost ophthalmic solution throughout the study.

Main Results:

  • Brinzolamide significantly reduced overall 24-hour IOP by 9.7±4.5%.
  • Daytime IOP was reduced by 9.5±4.7% and nighttime IOP by 10.3±5.6%.
  • The addition of brinzolamide demonstrated an additive IOP-lowering effect.

Conclusions:

  • Brinzolamide provides additive IOP-lowering effects when used in combination with latanoprost.
  • This combination therapy effectively reduces diurnal IOP fluctuations in glaucoma patients.
  • Brinzolamide may be a valuable addition to latanoprost for comprehensive glaucoma treatment.
Keywords:
Brinzolamideadditive effectdiurnal IOP changesintraocular pressure.latanoprost

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Last Updated: Jun 22, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
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High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013