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Related Experiment Video

Updated: Jun 22, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
12:33

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

[Not Available].

Serge A Mitelman1, Emily L Canfield, Randall E Newmark

  • 1Department of Psychiatry, Mount Sinai School of Medicine, New York, USA. serge.mitelman@mssm.edu

The Open Neuroimaging Journal
|June 24, 2009
PubMed
Summary
This summary is machine-generated.

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Schizophrenia patients show less brain volume change over time compared to healthy individuals. However, poor-outcome patients experience accelerated gray matter loss, suggesting earlier aging-related changes.

Area of Science:

  • Neuroimaging
  • Psychiatry
  • Neurology

Background:

  • Previous research indicates ongoing gray matter loss in schizophrenia post-clinical onset.
  • Longitudinal studies on white matter changes in chronic schizophrenia have yielded inconclusive results.

Purpose of the Study:

  • To investigate longitudinal changes in white matter and gray matter volumes in chronic schizophrenia patients.
  • To compare these changes between good-outcome and poor-outcome schizophrenia patient groups and healthy subjects.

Main Methods:

  • Utilized diffusion-tensor imaging and structural magnetic resonance imaging.
  • Scanned 49 chronic schizophrenia patients (good and poor outcome) and 16 healthy subjects twice over 4 years.
  • Analyzed fractional anisotropy and regional gray/white matter volumes using multiway ANCOVAs.
Keywords:
Kraepelinian schizophreniaanisotropyillness progression.poor outcomewhite matter

Related Experiment Videos

Last Updated: Jun 22, 2026

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
12:33

High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities

Published on: November 15, 2013

Main Results:

  • Schizophrenia patients initially showed reduced white matter anisotropy and increased white matter volumes, alongside smaller gray matter volumes.
  • Healthy subjects exhibited more pronounced declines in anisotropy and gray matter, and expansion of white matter volumes over time compared to patients.
  • Poor-outcome patients demonstrated greater gray matter loss and less white matter volume increase than good-outcome patients.

Conclusions:

  • Longitudinal changes in chronic schizophrenia tend to reduce initial gray and white matter differences between patients and healthy individuals.
  • White matter differences between good and poor outcome groups diminish over time.
  • Poor-outcome schizophrenia patients exhibit accelerated gray matter loss, consistent with earlier aging-associated changes.