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Updated: Jun 22, 2026
High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
Published on: November 15, 2013
[Not Available]
Joseph D Tobias1, Garry A Johnson, Saif Rehman
1Department of Anaesthesiology University of Missouri, Columbia, Missouri.
Background:
Changes in oxygenation occur during one-lung ventilation (OLV) due to intrapulmonary shunt. Although arterial oxygenation is generally adequate, there are no studies evaluating the effect of these changes on cerebral oxygenation.
Materials And Methods:
Cerebral oxygenation (rSO(2)), heart rate (HR), blood pressure (BP), oxygen saturation (SaO(2)), and end-tidal carbon dioxide (ETCO(2)) were prospectively monitored during OLV in adults. Cerebral oxygenation was monitored using near infrared spectroscopy. No clinical decisions were made based on the rSO2 value. BP and HR were the inspired oxygen concentration was adjusted as needed to maintain the SaO(2) >/= 95%.
Results:
The study cohort included 40 adult patients. 18,562 rSO(2) values were collected during OLV. The rSO(2) was >/= baseline at 3,593 of the 18,562 data points (19%). The rSO2 was 0-9 /= 25% of the duration of OLV. These patients were older (63.7 +/- 10.2 vs 54.6 +/- 9.8 years, P<0.025), weighed more (95.8 +/- 17.4 vs 82.6 +/- 14.6 kgs, P=0.038), and were more likely to be ASA III vs II (7 of 8 versus 25 of 32, relative risk 1.75) than the remainder of the cohort.
Conclusions:
Significant changes in rSO2 occur during OLV for thoracic surgical procedures. Future studies are needed to determine the impact of such changes on the postoperative course of these patients.
