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In Vivo Imaging Systems (IVIS) Detection of a Neuro-Invasive Encephalitic Virus
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Published on: December 2, 2012

Echovirus 30 associated with cases of aseptic meningitis in state of Pará, Northern Brazil

Ceyla Maria Oeiras de Castro1, Darleise S Oliveira, Olinda Macedo

  • 1Seção de Virologia, Instituto Evandro Chagas, Secretaria de Vigilância em Saúde, Ministério da Saúde, Ananindeua, Pará, Brasil.

Memorias Do Instituto Oswaldo Cruz
|June 24, 2009
PubMed

Insights

This study identified enterovirus (EV) in 19.8% of viral meningitis cases in Northern Brazil. Echovirus 30 was molecularly characterized, potentially forming a new phylogenetic subgroup.

Area of Science:

  • Virology
  • Epidemiology
  • Molecular Biology

Background:

  • Viral meningitis research in Brazil often overlooks Northern regions.
  • Enterovirus (EV) is a common cause of viral meningitis.

Purpose of the Study:

  • To describe viral meningitis cases in Pará, Northern Brazil (2005-2006).
  • To detect and characterize enteroviruses in cerebrospinal fluid samples.

Main Methods:

  • Cerebrospinal fluid analysis using cell culture, RT-PCR, nested PCR, and nucleotide sequencing.
  • Phylogenetic analysis of detected enterovirus strains.

Main Results:

  • Enterovirus (EV) was detected in 19.8% (18/91) of samples.
  • Echovirus 30 (Echo 30) was identified and sequenced.
  • Detected Echo 30 strains clustered uniquely, suggesting a potential new phylogenetic subgroup (4c).

Conclusions:

  • This study provides the first molecular characterization of Echovirus 30 in Brazil.
  • Findings contribute to understanding viral meningitis etiology in Northern Brazil and future molecular analyses.

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