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Published on: May 31, 2020
Dengue virus type 3 in Brazil: a phylogenetic perspective
Josélio Maria Galvão de Araújo1, Gonzalo Bello, Hermann Gonçalves Schatzmayr
1Laboratório de Flavivirus, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, Brasil. joselio@ioc.fiocruz.br
Memorias Do Instituto Oswaldo Cruz
|June 24, 2009
Summary
A new dengue virus (DENV)-3 genotype, classified as GV, has been identified in South America. Phylogenetic analysis confirms its distinctness and raises questions about its origins, given its genetic similarity to an older strain.
Area of Science:
- Virology
- Genetics
- Epidemiology
Background:
- A novel dengue virus (DENV)-3 genotype recently emerged in Brazil and Colombia.
- The classification of this new genotype has been a subject of scientific debate.
Purpose of the Study:
- To perform phylogenetic and nucleotide-distance analyses of the DENV-3 envelope gene.
- To precisely classify the new South American DENV-3 genotype.
Main Methods:
- Phylogenetic analysis of the DENV envelope gene.
- Nucleotide-distance analysis of DENV-3 strains.
Main Results:
- DENV-3 strains can be subdivided into five distinct genotypes (GI-GV).
- The new South American genotype is confirmed as genotype GV.
- Extremely low genetic distances were observed between Brazilian GV strains and the 1956 Philippines GV strain.
Conclusions:
- The classification of the new South American DENV-3 genotype as GV is confirmed.
- The close genetic relationship between South American GV strains and an early isolate suggests potential long-term circulation or a specific introduction event.
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