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Differential diagnosis and treatment of primary, cutaneous, anaplastic large cell lymphoma: not always an easy task
Michael D Diamantidis1, Athanasios Papadopoulos2, Georgia Kaiafa2
1Department of Hematology, First Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, 1 S. Kiriakidi St, 546 36, Thessaloniki, Greece. diamantidis79@yahoo.gr.
Abstract:
Primary cutaneous anaplastic large cell lymphoma (PC-ALCL) is a rare and distinct neoplasm appearing de novo on the skin. We present a case of a 75-year-old man diagnosed with PC-ALCL in his left femoral region. We describe the morphology of lesions along with the differential diagnosis, treatment, clinical course and prognosis. We further discuss parameters concerning treatment that should be considered when a PC-ALCL is diagnosed. Our case report demonstrates the complexity in classification, staging, differential diagnosis and therapy selection of PC-ALCLs. It is crucial to emphasize the importance of clinical criteria in diagnosing a PC-ALCL in combination with immunohistochemistry.
