Related Experiment Video
Updated: Jun 22, 2026

Monitoring Blood Glucose in Mouse Offspring After Intracytoplasmic Sperm Injection
Published on: May 17, 2024
Does the genetic and familial background of males undertaking ICSI affect the outcome?
M Maiburg1, B Alizadeh, P Kastrop
1Department of Medical Genetics, University Medical Center Utrecht, 3508 AB Utrecht, The Netherlands. m.maiburg@umcutrecht.nl
Purpose:
To investigate whether the success rate of ICSI is (1) related to the etiology of infertility or (2) adversely affected by a family history of potential genetic disorders.
Methods:
All men with an ICSI indication in our hospital between 1994 and 2005 were included in our cohort study. Data on the ICSI process, etiology of infertility, and family history were collected. ICSI success rates of infertility subgroups and a subgroup with a positive family history were compared to a group with unknown etiology and a negative family history.
Results:
There was no significant difference in clinical pregnancy or delivery rates between the subgroups. Couples achieving a pregnancy underwent significantly more ICSI cycles compared to couples not achieving a pregnancy.
Conclusion:
Our results suggest that the success rate of ICSI treatment is not related to the cause of infertility or a family history positive for potential genetic disorders.
Related Concept Videos
Infertility in Males
Genomic Imprinting and Inheritance
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Behavioral Genetics and Its Designs
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
Infertility in Females
Endometriosis, a condition characterized by abnormal growth of endometrial...
Spermatogenesis
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...

