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Does insulin species modify counterregulatory hormone response to hypoglycemia?
T W Jones1, S Caprio, M P Diamond
1Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06510-8064.
Diabetes Care
|August 1, 1991
Summary
Pork and human insulin trigger similar hormonal responses during controlled hypoglycemia in healthy adults. This suggests comparable efficacy in managing blood sugar levels.
Area of Science:
- Endocrinology
- Metabolic Research
- Pharmacology
Background:
- Insulin therapy is crucial for managing diabetes.
- Understanding the physiological responses to different insulin types is important for clinical practice.
Purpose of the Study:
- To compare the counterregulatory hormonal responses to induced hypoglycemia using pork versus human insulin.
Main Methods:
- Utilized the glucose-clamp technique in 35 healthy adults to standardize glucose and insulin levels.
- Administered either pork or human regular insulin to induce mild hypoglycemia.
- Monitored plasma glucose and counterregulatory hormone levels.
Main Results:
- Achieved similar steady-state insulin levels and plasma glucose reduction in both groups.
- Observed nearly identical hormonal responses, including epinephrine, norepinephrine, glucagon, growth hormone, and cortisol.
- No significant differences were found in peak hormone levels between pork and human insulin groups.
Conclusions:
- Pork and human insulin elicit comparable and robust counterregulatory hormonal responses in healthy adults during controlled hypoglycemia.
- These findings support the interchangeability of pork and human insulin in terms of hormonal response under these specific conditions.