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Acute hyperglycemia and spontaneous reperfusion in acute myocardial infarction

David Leibowitz1, Johannes Nowatzky, A Teddy Weiss

  • 1Coronary Care Unit, Hadassah-Hebrew University Medical Center, Mount Scopus, Jerusalem, Israel. oleibo@hadassah.org

Acute Cardiac Care
|June 24, 2009
PubMed

Insights

Acute hyperglycemia in ST-elevation myocardial infarction (STEMI) patients does not predict spontaneous reperfusion (SR). This finding suggests blood sugar levels on admission do not influence early coronary artery recovery in STEMI cases.

Area of Science:

  • Cardiology
  • Metabolic Syndrome

Background:

  • Spontaneous reperfusion (SR) is a potential outcome in ST-elevation myocardial infarction (STEMI) before intervention.
  • Hyperglycemia on admission is frequent in STEMI and linked to poorer outcomes, possibly due to impaired coronary flow.

Purpose of the Study:

  • To investigate the association between acute hyperglycemia and the occurrence of SR in STEMI patients.

Main Methods:

  • Studied 465 STEMI patients with admission glucose measurements.
  • Defined SR by significant chest pain relief and >=70% ST-segment elevation resolution on ECG.

Main Results:

  • No significant difference in average glucose levels between SR and non-SR groups (10.0+/-5.6 vs. 10.1+/-5.3 mmol/l).
  • Similar percentages of normoglycemic and hyperglycemic patients observed in both SR (52%) and non-SR (54%) groups.

Conclusions:

  • Acute hyperglycemia upon admission does not appear to predict spontaneous reperfusion in STEMI patients.
Abstract

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