Tracking algorithms chase down pathogens
Related Experiment Video
Updated: Jun 22, 2026

High-Resolution Three-Dimensional Whole-Organ Tomography of Microbial Infections
Published on: March 1, 2024
Nicolas Chenouard1, Alexandre Dufour, Jean-Christophe Olivo-Marin
1Institut Pasteur, Unité d'Analyse d'Images Quantitative, CNRS URA 2582, Paris, France.
Abstract:
Understanding subcellular dynamic processes governing pathogenic mechanisms is a necessary step towards the development of new drugs and strategies against infectious diseases. Subcellular pathogenic mechanisms, such as viral invasion processes involve highly dynamic nanometric-scale objects and rapid molecular interactions that require the study of individual particle paths. Single-particle tracking methods allow visualizing and characterizing the dynamics of biological objects, and provide a straightforward and accurate means to understand subcellular processes. This review describes a number of particle-tracking methods in time-lapse microscopy sequences and provides examples of using such techniques to investigate mechanisms of host-pathogen interactions.
Related Concept Videos
Rapid Identification of Pathogens
Colonisation of Pathogens
Investigation of Disease Outbreaks
Intracellular Movement of Viruses and Bacteria
Steps in Outbreak Investigation
Infection
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...

