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Related Experiment Videos

Multiple peritoneal cytologies collected during laparotomy for gynecologic malignancy.

S M Jacques1, S M Selvaggi

  • 1Department of Pathology, Hutzel Hospital, Wayne State University School of Medicine, Detroit, MI 48201.

Diagnostic Cytopathology
|January 1, 1991
PubMed
Summary

Peritoneal cytology, including washings and diaphragmatic smears, has limited utility in diagnosing gynecologic malignancy. Most positive results correlated with known disease, offering little benefit in detecting occult spread.

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Area of Science:

  • Gynecologic Oncology
  • Surgical Pathology
  • Cytopathology

Background:

  • Peritoneal cytology is utilized in evaluating gynecologic malignancies.
  • Diagnostic yield of peritoneal washings and diaphragmatic smears requires further investigation.

Purpose of the Study:

  • To assess the diagnostic value of peritoneal washings and diaphragmatic smears.
  • To determine the utility of these methods in detecting gynecologic malignancy spread.

Main Methods:

  • Retrospective review of 18 months of peritoneal cytology specimens.
  • Analysis of 760 peritoneal washings and 177 diaphragmatic smears from 300 laparotomies.
  • Correlation of cytology results with patient diagnosis and extent of disease.

Main Results:

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  • Only 35 of 197 patients with gynecologic malignancy had positive peritoneal cytologies.
  • Positive cytology results generally correlated with gross or microscopic peritoneal involvement.
  • Diaphragmatic smears were positive in only three cases, all with advanced ovarian carcinoma.

Conclusions:

  • Analysis of multiple peritoneal washings and diaphragmatic smears offers benefit in few cases.
  • Peritoneal cytology has limited utility in detecting occult gynecologic malignancy.
  • Current methods show low yield for diaphragmatic smears, especially without gross disease.