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Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

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Related Experiment Video

Updated: Jun 22, 2026

A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta
11:44

A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta

Published on: September 27, 2017

Maternal obesity as a perinatal risk factor.

Piotr Hincz1, Dariusz Borowski, Michał Krekora

  • 1Department of Maternal-Fetal Medicine & Gynecology, Polish Mother's Memorial Hospital, Lod, Poland. phincz@o2.pl

Ginekologia Polska
|June 25, 2009
PubMed
Summary

Maternal obesity increases risks for pregnancy complications like hypertension and gestational diabetes. Obese mothers also have higher rates of delivering macrosomic babies, indicating a significant perinatal risk factor.

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Area of Science:

  • Perinatal Medicine
  • Obstetrics
  • Maternal Health

Background:

  • Maternal obesity is a growing global health concern.
  • Understanding its impact on pregnancy outcomes is crucial for clinical practice.

Purpose of the Study:

  • To evaluate the effects of maternal obesity on pregnancy, delivery, and newborn well-being.
  • To identify specific risks associated with obesity during pregnancy.

Main Methods:

  • Retrospective analysis of delivery data from PMMH.
  • Comparison of outcomes between obese pregnant women (BMI ≥30) and a control group.
  • Assessment of pregnancy course, labor, delivery, and newborn health indicators.

Main Results:

  • Obese mothers had higher incidences of pregnancy-associated hypertension (8.65% vs 2.39%) and preeclampsia (4.81% vs 1.58%).
  • Gestational diabetes mellitus requiring insulin therapy (9.62% vs 1.48%) and polyhydramnios (4.81% vs 2.11%) were more frequent in obese women.
  • Newborns of obese mothers had higher mean birthweight (3266g vs 3100g) and increased rates of macrosomia (20.19% vs 5.69%).
  • Elective cesarean section rates were higher in obese mothers (27.88% vs 19.90%).

Conclusions:

  • Maternal obesity is a significant perinatal risk factor.
  • Common complications include pregnancy-associated hypertension and gestational diabetes requiring insulin therapy in mothers, and macrosomia in newborns.
  • These findings underscore the need for targeted interventions for obese pregnant individuals.