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Related Experiment Video

Updated: Jun 22, 2026

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

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Published on: August 17, 2022

Ectopic parathyroid adenoma in child.

P Libánský¹, J Astl, S Adámek

¹Charles University in Prague, First Faculty of Medicine and Teaching Hospital Motol, Third Department of Surgery, Prague, Czech Republic.

Prague Medical Report

|June 25, 2009

Summary

A rare case of ectopic thymic adenoma causing hypercalcemia in a child was diagnosed after initial imaging was inconclusive. Surgical removal successfully resolved the persistent hypercalcemia and bone lesions.

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Area of Science:

Pediatric Endocrinology
Surgical Oncology
Nuclear Medicine

Background:

Ectopic thymic adenomas are rare and can present with unusual symptoms, including hypercalcemia.
Pediatric hypercalcemia requires thorough investigation to identify underlying causes, which can be challenging.

Observation:

A 10-year-old girl presented with fatigue, hypercalcemia, and osteolytic bone lesions.
Initial imaging suggested a thyroidal or parathyroidal mass, but exploration revealed thymic tissue without an adenoma.
Despite extensive imaging, the ectopic adenoma was only located by MIBI-SPECT/CT near the left jugulum after two years of worsening symptoms.

Findings:

Histological examination confirmed thymic tissue, not a typical adenoma.
Persistent hypercalcemia and decreasing bone mineral density indicated an ongoing issue.
MIBI-SPECT/CT successfully localized the ectopic thymic adenoma, which was surgically removed.

Implications:

This case highlights the diagnostic challenges of ectopic thymic adenomas, especially in pediatric hypercalcemia.
Advanced nuclear imaging techniques like MIBI-SPECT/CT are crucial for locating elusive ectopic endocrine tissue.
Timely diagnosis and surgical excision of ectopic thymic adenomas can effectively manage hypercalcemia and prevent bone loss.