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Solar urticaria successfully treated with intravenous immunoglobulin
R Hughes1, C Cusack, G M Murphy
1Department of Dermatology, The Adelaide and Meath Hospital, Incorporating the National Children's Hospital Tallaght, Dublin, Ireland.
Clinical and Experimental Dermatology
|June 25, 2009
Summary
Severe solar urticaria (SU) can be effectively treated with intravenous immunoglobulin (IVIg). This treatment offers long-term remission for patients resistant to conventional therapies.
Area of Science:
- Dermatology
- Immunology
Background:
- Idiopathic solar urticaria (SU) is a rare, debilitating skin condition triggered by sunlight.
- Conventional treatments like antihistamines and phototherapy often provide only short-term relief.
Observation:
- Two cases of severe, treatment-resistant idiopathic SU were identified.
- Both patients experienced complete remission following treatment with intravenous immunoglobulin (IVIg).
Findings:
- IVIg, administered in multiple courses at a dose of 2 g/kg, proved effective for severe idiopathic SU.
- Remission was sustained for 13 months and 4 years in the two reported cases.
Implications:
- IVIg represents a promising therapeutic option for severe, refractory cases of solar urticaria.
- While generally safe, potential risks associated with IVIg, such as infection or anaphylaxis, should be considered.
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