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Updated: Jun 22, 2026
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
[A comparative study of in-stent restenosis after drug eluting stents]
Zhan Gao1, Yue-Jin Yang, Ji-Lin Chen
1Coronary Heart Disease Division, Cardiovascular Institute, Fuwai Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100037, China.
Insights
This study found that Cypher, Taxus, and Firebird drug-eluting stents (DES) showed similar long-term safety and effectiveness for in-stent restenotic lesions. However, Cypher and Firebird DES demonstrated a better effect in reducing restenosis rates.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Biomaterials Science
Background:
- Drug-eluting stents (DES) are crucial for managing in-stent restenosis.
- Comparing the long-term outcomes of different DES is essential for clinical decision-making.
Purpose of the Study:
- To compare the long-term clinical and angiographic effectiveness and safety of three DES: Cypher, Taxus, and Firebird.
- To evaluate their performance in patients with in-stent restenotic lesions.
Main Methods:
- A single-center study involving 390 patients with in-stent restenotic lesions.
- Patients received either Cypher (n=187), Taxus (n=89), or Firebird (n=114) DES.
- Follow-up included 2 years for clinical events and 7 months for angiographic assessment.
Main Results:
- No significant differences were observed in major adverse cardiac events (MACE), cardiac death, myocardial infarction, or target vessel revascularization rates at 2 years.
- No significant differences were found in total stent thrombosis rates (definite + probable) among the groups.
- Cypher and Firebird DES showed a trend towards lower in-stent and in-segment restenosis rates and significantly smaller in-stent and in-segment late loss at 7-month angiographic follow-up.
Conclusions:
- Cypher, Taxus, and Firebird DES demonstrate comparable long-term effectiveness and safety in treating in-stent restenotic lesions.
- Cypher and Firebird DES appear to offer superior outcomes in reducing restenosis.
- Further research may explore the specific mechanisms contributing to these differences.
Objective:
To compare the long-term effect of three different drug-eluting stents (DES) for in-stent restenotic lesions.
Methods:
From April 2004 to June 2006, 390 consecutive patients undergoing DES implantation including 187 Cypher (group C), 89 Taxus (group T) and 114 Firebird (group F) with resulting in-stent restenotic lesions were studied. A mean of 2 year clinical and 7-month angiographic follow-up was carried out.
Results:
Baseline characteristics indicated that there were more unstable angina cases in T group and less left main disease and more triple vessel disease cases in F group. A mean of 2-year follow-up results showed no difference of major adverse cardiac events (MACE) rate among the three groups (23.0% vs 22.5% vs 13.2%, P = 0.081) and no difference of cardiac death, non-fatal myocardial infarction (MI) and target vessel revascularization rate (1.1% vs 4.5% vs 1.8%, P = 0.210, 5.9% vs 2.2% vs 2.6%, P = 0.226 and 2.9% vs 2.2% vs 0.9%, P = 0.509). There was no difference of total stent thrombosis or its components among the three groups (total: 4.8% vs 3.4% vs 2.6%, P = 0.605, early: 0.5% vs 0 vs 0.9%, P = 0.560, late: 1.6% vs 1.1% vs 0.9%, P = 0.849 and very late: 2.9% vs 2.2% vs 0.9%, P = 0.509) according to Academic Research Consortium (ARC) standard definitions (definite + probable). 7-month angiographic follow-up indicated that there was a lower trend of both in-stent and in-segment restenosis rate in C and F groups (17.9% vs 29.4% vs 13.6%, P = 0.214 and 21.8% vs 35.3% vs 15.9%, P = 0.132)and in-stent and in-segment late loss was significantly smaller in C and F groups [(0.31 +/- 0.12) mm vs (0.75 +/- 0.24) mm vs (0.31 +/- 0.13) mm, P = 0.000 and (0.33 +/- 0.18) mm vs (0.61 +/- 0.23) mm vs (0.31 +/- 0.14) mm, P = 0.001].
Results:
from this 2-year follow-up, single-center study showed comparable effectiveness and safety of Cypher, Taxus and Firebird DES for in-stent restenotic lesions, but Cypher and Firebird had better effect in reducing restenosis.