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Immunohistochemical Detection of 5-Methylcytosine and 5-Hydroxymethylcytosine in Developing and Postmitotic Mouse Retina
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Oxygenase catalyzed 5-methylcytosine hydroxylation

Christoph Loenarz1, Christopher J Schofield

  • 1Chemistry Research Laboratory and The Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.

Chemistry & Biology
|June 25, 2009
PubMed
Summary

Recent reports identify the oxygenase catalyzed production of 5-hydroxymethylcytosine as a modification to mammalian DNA. This discovery has potential far-reaching implications for epigenetic regulation and will stimulate efforts to identify new nucleic acid modifications.

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