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Updated: Jun 22, 2026

Characterizing Modulators of Protease-Activated Receptors with a Calcium Mobilization Assay Using a Plate Reader
07:13

Characterizing Modulators of Protease-Activated Receptors with a Calcium Mobilization Assay Using a Plate Reader

Published on: May 24, 2024

New P2Y12 antagonists.

Alan D Michelson1

  • 1Center for Platelet Research Studies, Children's Hospital Boston, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115-5737, USA. alan.michelson@childrens.harvard.edu

Current Opinion in Hematology
|June 25, 2009
PubMed
Summary
This summary is machine-generated.

New P2Y12 antagonists offer improved platelet inhibition compared to clopidogrel. Their clinical benefit and safety profile require further investigation for antithrombotic therapy.

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Characterizing Modulators of Protease-Activated Receptors with a Calcium Mobilization Assay Using a Plate Reader
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Published on: July 17, 2020

Area of Science:

  • Cardiovascular Pharmacology
  • Thrombosis and Hemostasis

Background:

  • Clopidogrel is a widely used P2Y12 antagonist for antithrombotic therapy.
  • Disadvantages of clopidogrel have driven the development of novel P2Y12 antagonists.

Purpose of the Study:

  • To review the current status of clopidogrel.
  • To discuss novel P2Y12 antagonists and their potential advantages.

Main Methods:

  • Review of existing literature on clopidogrel and novel P2Y12 antagonists.
  • Analysis of factors affecting clopidogrel metabolism and response.

Main Results:

  • Poor response to clopidogrel correlates with poor clinical outcomes.
  • Factors like CYP2C19 alleles and drug interactions influence clopidogrel metabolism.
  • Novel P2Y12 antagonists demonstrate more rapid, variable, and complete platelet inhibition.

Conclusions:

  • The clinical utility of tailoring clopidogrel therapy based on platelet function or genetic testing remains unproven.
  • New P2Y12 antagonists are being evaluated for superior antithrombotic efficacy and safety compared to clopidogrel.