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Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Formation of the Platelet Plug01:22

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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
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Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
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The Proteasome Structure01:17

The Proteasome Structure

The ubiquitin-proteasome pathway is a well-known mechanism utilized by eukaryotic cells to remove cytoplasmic proteins that are misfolded, damaged, or no longer needed. In this pathway, the protein that needs to be eliminated undergoes a process called ubiquitination, where a chain of ubiquitin molecules is attached to the 48th lysine residue of the target protein. This ubiquitin modification helps the proteasome distinguish between a target protein and a healthy protein.
The proteasome is an...

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Related Experiment Video

Updated: Jun 22, 2026

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry
08:04

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

Published on: June 10, 2025

The platelet proteome.

Lisa Senzel1, Dmitri V Gnatenko, Wadie F Bahou

  • 1Department of Pathology, University Hospital, State University of New York, Stony Brook, NY 11794-7300, USA. lsenzel@notes.cc.sunysb.edu

Current Opinion in Hematology
|June 25, 2009
PubMed
Summary
This summary is machine-generated.

Proteomics has identified over 1100 platelet proteins, revealing new signaling pathways and secreted proteins. These findings offer potential therapeutic targets for bleeding and clotting disorders and novel cancer biomarkers.

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Related Experiment Videos

Last Updated: Jun 22, 2026

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry
08:04

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

Published on: June 10, 2025

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism
06:04

LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism

Published on: April 4, 2016

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Hematology

Background:

  • The proteome represents the full set of proteins expressed under specific conditions.
  • Proteomics encompasses technologies for protein visualization, quantification, and identification.
  • Platelet research is crucial for understanding bleeding, clotting, transfusion medicine, and angiogenesis.

Purpose of the Study:

  • To review recent advances in proteomics applied to platelet biology.
  • To highlight the relevance of platelet proteomics to various medical conditions.
  • To explore the potential of proteomics in identifying novel therapeutic targets and biomarkers.

Main Methods:

  • Proteomic techniques for protein analysis.
  • Characterization of various platelet subproteomes.
  • Integration of proteomic data into accessible databases.

Main Results:

  • Identification of over 1100 platelet proteins.
  • Characterization of platelet releasates, granules, membrane proteins, and microparticles.
  • Detailed analysis of the platelet phosphoproteome.

Conclusions:

  • Proteomic studies have uncovered novel signaling pathways in platelets.
  • Identification of secreted proteins with potential as therapeutic targets.
  • Discovery of potential cancer biomarkers through platelet proteomic analysis.