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Related Concept Videos

Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase, which converts...
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Certain drugs can affect how neurotransmitters called catecholamines, are released or taken back up in the adrenergic neuron. They can have different effects on the body's sympathetic transmission. Reserpine, a natural compound found in the Rauwolfia shrub, blocks a transporter called vesicular monoamine transporter (VMAT), which leads to a buildup of catecholamines in the cell and reduces sympathetic transmission. Another drug called guanethidine works in multiple ways, including blocking...
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Neurochemical transmission, the conduction of electrical impulses between neurons mediated by neurotransmitters, plays a vital role in various physiological processes. Autonomic drugs exert their effects by modulating neurotransmission within the autonomic nervous system. For instance, drugs such as hemicholinium block the precursor uptake necessary for synthesizing acetylcholine, an essential autonomic neurotransmitter. Following synthesis, neurotransmitters are stored in vesicles. Metyrosine...
Parkinson's Disease: Treatment01:24

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Related Experiment Video

Updated: Jun 22, 2026

Presynaptic Dopamine Dynamics in Striatal Brain Slices with Fast-scan Cyclic Voltammetry
08:49

Presynaptic Dopamine Dynamics in Striatal Brain Slices with Fast-scan Cyclic Voltammetry

Published on: January 12, 2012

Cardiac repolarization and striatal dopamine transporter function are interrelated.

Esa Kauppila1, Esko Vanninen, Tom Kuusela

  • 1Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland. esa.kauppila@fimnet.fi

Nuclear Medicine Communications
|June 25, 2009
PubMed
Summary

This study found a significant link between striatal dopamine transporter (DAT) binding and cardiac repolarization time (QTc interval) in healthy young adults. This QTc-DAT relation suggests QTc measurements may offer diagnostic insights for conditions affecting both brain and heart function.

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Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area
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08:49

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09:54

Comprehensive Profiling of Dopamine Regulation in Substantia Nigra and Ventral Tegmental Area

Published on: August 10, 2012

Area of Science:

  • Neuroscience
  • Cardiology
  • Autonomic Nervous System Function

Background:

  • Parkinson's disease is associated with disrupted striatal dopamine transporter (DAT) binding and impaired cardiac sympathetic function.
  • Prolonged heart rate (HR)-corrected cardiac repolarization time (QTc interval), influenced by autonomic control, is also observed.
  • The physiological relationship between striatal DAT binding and QTc interval (QTc-DAT relation) remains uncharacterized.

Purpose of the Study:

  • To investigate the potential physiological coupling between striatal DAT binding and QTc interval in healthy young adults.

Main Methods:

  • Thirty-five healthy young adults (mean age 26.4 years) underwent iodine-123 labelled 2beta-carbomethoxy-3beta-(4-iodophenyl) nortropane single photon emission tomography for striatal DAT binding assessment.
  • Resting electrocardiogram (ECG) was recorded, and QTc intervals were calculated using Bazett's and Karjalainen's corrections (QTc and QTk, respectively).
  • Statistical analyses explored correlations between striatal DAT binding, heart rate, and QTc/QTk intervals.

Main Results:

  • A significant negative correlation was found between striatal DAT binding and both QTc (r = -0.50, P = 0.004) and QTk intervals (r = -0.59, P = 0.0002).
  • Striatal DAT binding explained 35% of the variance in the QTk interval.
  • Heart rate was not significantly related to striatal DAT binding but showed a strong negative correlation with the QT interval (r = -0.63, P < 0.001).

Conclusions:

  • A significant physiological QTc-DAT relation exists in young healthy adults.
  • QTc interval measurements may provide valuable diagnostic information in clinical contexts impacting both striatal DAT binding and cardiac sympathetic function.