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Related Concept Videos

Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Hypoxia01:23

Hypoxia

Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...

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Updated: Jun 22, 2026

Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance
07:07

Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance

Published on: February 14, 2025

Tumor hypoxia and malignant progression.

S Osinsky1, M Zavelevich, P Vaupel

  • 1R.E. Kavetsky Insitute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kyiv 03022, Ukraine. osion@onconet.kiev.ua

Experimental Oncology
|June 25, 2009
PubMed
Summary
This summary is machine-generated.

Tumor hypoxia is a key factor in malignant progression, influencing tumor aggressiveness and patient prognosis. Understanding hypoxia-associated signaling, metabolism, and inflammation is crucial for developing new cancer treatments.

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Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance
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Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Discusses the molecular mechanisms of the tumor microenvironment and its role in tumor progression.
  • Highlights tumor hypoxia as a critical factor promoting cancer aggressiveness and unfavorable prognosis.
  • Addresses the interaction between tumor cells and stromal cells in mediating tumor behavior.

Framework:

  • Focuses on tumor hypoxia, aerobic glycolysis, and their link to malignant tumors.
  • Explores the stimulating impact of hypoxia on neoangiogenesis and vasculogenesis.
  • Investigates the association between hypoxia-dependent signaling and inflammatory factors like tumor-associated macrophages.

Implementation:

  • Reviews methods for evaluating tumor hypoxia levels, some clinically applicable.
  • Discusses the development of agents targeting hypoxia-associated signaling pathways and vasculogenesis.
  • Examines the relationship between hypoxia, metabolic peculiarities, and inflammatory factors.

Implications:

  • A deeper understanding of hypoxia's role can elucidate aggressive tumor phenotype formation.
  • Findings may assist in developing novel therapeutic strategies for cancer patients.
  • Emphasizes the importance of studying hypoxia-associated signaling, metabolism, and inflammation for cancer treatment.