Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Evolutionary Relationships through Genome Comparisons

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...

What is Population Genetics?

What is Population Genetics?

A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.While some alleles of a given gene might be observed commonly, other variants...

Gene Evolution - Fast or Slow?

Gene Evolution - Fast or Slow?

The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...

Gene Evolution - Fast or Slow?

Gene Evolution - Fast or Slow?

The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...

Pedigree Analysis

Pedigree Analysis

Pedigree Analysis

Pedigree Analysis

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Discovery of gene-alcohol interaction loci influencing blood pressure in 1.1 million individuals from multiple populations.

Research square·2026

Same author

Low Cholesterol due to APOB Variants: Exploring the Balance Between Liver and Cardiovascular Risk.

Liver international : official journal of the International Association for the Study of the Liver·2026

Same author

Large-Scale Gene-Smoking Interactions and Fine Mapping Study Identifies Multiple Novel Blood Pressure Loci in over 1 Million Individuals.

medRxiv : the preprint server for health sciences·2026

Same author

A human CAGinSTEM platform for decoding HTT repeats' somatic instability links CAG interruption to HD pathology in neurons.

Cell reports·2025

Same author

Machine learning models incorporating genotype and ancestry improve severe asthma risk prediction.

Scientific reports·2025

Same author

Development and Statistical Validation of the Metabolic Surgery Indication Score: Standardized Procedure Selection in Metabolic and Bariatric Surgery.

Obesity facts·2025

Search research articles

Related Experiment Video

Updated: Jun 22, 2026

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

Comparing population structure as inferred from genealogical versus genetic information.

Vincenza Colonna¹, Teresa Nutile, Ronald R Ferrucci

¹Dipartimento di Biologia ed Evoluzione, Università di Ferrara, Ferrara, Italy.

European Journal of Human Genetics : EJHG

|June 25, 2009

Summary

Genetic clustering accurately identifies related individuals in isolated villages, even with low genetic differentiation. This confirms that genetic markers can reveal population structure mirroring genealogical relationships.

More Related Videos

Simultaneous Assessment of Kinship, Division Number, and Phenotype via Flow Cytometry for Hematopoietic Stem and Progenitor Cells

Simultaneous Assessment of Kinship, Division Number, and Phenotype via Flow Cytometry for Hematopoietic Stem and Progenitor Cells

Published on: March 24, 2023

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

Published on: August 12, 2019

Related Experiment Videos

Last Updated: Jun 22, 2026

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

Simultaneous Assessment of Kinship, Division Number, and Phenotype via Flow Cytometry for Hematopoietic Stem and Progenitor Cells

Simultaneous Assessment of Kinship, Division Number, and Phenotype via Flow Cytometry for Hematopoietic Stem and Progenitor Cells

Published on: March 24, 2023

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

Published on: August 12, 2019

Area of Science:

Population Genetics
Human Evolutionary Studies
Bioinformatics

Background:

Population assignment methods effectively identify genetic clusters in human populations.
Empirical testing of these methods in scanty-differentiated populations for identifying related individuals is lacking.

Purpose of the Study:

To empirically test the performance of genetic clustering algorithms in identifying genealogically related individuals.
To assess the ability of genetic data to reflect population structure in closely related, isolated populations.

Main Methods:

Utilized both genealogical and genetic data from two isolated villages in southern Italy.
Employed genetic clustering analysis to identify population structure.
Estimated average kinship from genealogies and group membership from genetic data.

Main Results:

Genetic clustering identified two distinct clusters corresponding to the two villages, despite low inter-village F(st) (0.008).
Average kinship increased with higher genetic group membership, indicating clusters represent more closely related individuals.
Increasing membership stringency heightened average kinship within clusters and inter-cluster F(st).

Conclusions:

A limited number of genetic markers suffice to detect population structure.
Genetic analyses accurately mirror genealogical structuring, even in populations with low genetic differentiation.
The study highlights the utility of genetic clustering for understanding fine-scale population relationships.