Retinally stabilized cone-targeted stimulus delivery
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Updated: Jun 22, 2026

Optimized Minimally Invasive Transscleral Subretinal Injection Technique in Mouse
Published on: July 25, 2025
Abstract:
We demonstrate projection of highly stabilized, aberration-corrected stimuli directly onto the retina by means of real-time retinal image motion signals in combination with high speed modulation of a scanning laser. In three subjects with good fixation stability, stimulus location accuracy averaged 0.26 arcminutes or approximately 1.3 microns, which is smaller than the cone-to-cone spacing at the fovea. We also demonstrate real-time correction for image distortions in adaptive optics scanning laser ophthalmoscope (AOSLO) with an intraframe accuracy of about 7 arcseconds.
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