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Shape based Monte Carlo code for light transport in complex heterogeneous Tissues.

Eduardo Margallo-Balbás, Patrick J French

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    A new Monte Carlo code simulates light transport in complex biological tissues. This tool accurately models optical properties, particularly in bone

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    Area of Science:

    • Biomedical Optics
    • Computational Physics
    • Medical Imaging

    Background:

    • Accurate simulation of light transport in heterogeneous scattering media is crucial for biomedical optics.
    • Existing methods often struggle with complex, realistic geometries.
    • Understanding light-tissue interaction is key for developing new optical diagnostic and therapeutic tools.

    Purpose of the Study:

    • To present and validate a novel Monte Carlo code for light transport simulation.
    • To enable flexible modeling of realistic heterogeneous scattering media using triangle meshes.
    • To investigate the impact of trabecular bone structure on optical properties.

    Main Methods:

    • Developed a Monte Carlo code utilizing triangle meshes for material interfaces.
    • Implemented a hierarchical spatial organization for efficient photon-surface intersection tests.
    • Applied the code to a microCT-derived model of trabecular bone to simulate light distribution and compute time-resolved curves.

    Main Results:

    • The code successfully simulates light transport in heterogeneous scattering media.
    • Demonstrated the impact of trabecular bone microstructure on optical properties.
    • Generated time-resolved light transport curves within a spherical bone model.

    Conclusions:

    • The developed Monte Carlo code is a powerful and flexible tool for simulating radiative transport in complex, reality-based tissue models.
    • This approach allows for a detailed study of heterogeneity effects in biomedical optics.
    • Enables more accurate predictions of light-tissue interactions for various biomedical applications.