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SERS-based detection in an optofluidic ring resonator platform.

Ian M White, John Gohring, Xudong Fan

    Optics Express
    |June 25, 2009
    PubMed
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    This study presents an optofluidic ring resonator (OFRR) for highly sensitive surface-enhanced Raman scattering (SERS) detection. This lab-on-a-chip SERS tool achieves a 400 pM detection limit for R6G, enabling low-molecule detection.

    Area of Science:

    • Optofluidics
    • Spectroscopy
    • Nanotechnology

    Background:

    • Surface-enhanced Raman scattering (SERS) has enabled highly sensitive detection using Raman spectroscopy.
    • Development of lab-on-a-chip SERS sensors is crucial for bio/chemical analysis but faces limitations.
    • Integrated microfluidics are essential for efficient sample handling in SERS devices.

    Purpose of the Study:

    • To develop a novel SERS-based detection tool integrated with microfluidics.
    • To utilize an optofluidic ring resonator (OFRR) platform for enhanced SERS detection.
    • To demonstrate the feasibility of a lab-on-a-chip SERS sensor for sensitive analyte detection.

    Main Methods:

    • An optofluidic ring resonator (OFRR) platform was employed, featuring a liquid core optical ring resonator (LCORR).

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  • The LCORR served as both the microfluidic channel for sample delivery and the optical resonator.
  • Metal nanoclusters and target analytes were excited as they passed through the OFRR channel.

    • Main Results:

    • A SERS-based detection limit of 400 pM was achieved using R6G as the analyte.
    • The detected Raman signal originated from a small number of R6G molecules (estimated few hundred).
    • The OFRR platform demonstrated effective integration of microfluidics and SERS detection.

    Conclusions:

    • The OFRR platform is a promising approach for developing integrated lab-on-a-chip SERS sensors.
    • This technology has the potential for highly sensitive detection of low concentrations of target analytes.
    • Further development could lead to advanced bio/chemical sensors with enhanced specificity and sensitivity.