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Updated: Jun 22, 2026

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Optimal self-referenced sensing using long- and short- range surface plasmons.

J T Hastings1, J Guo, P D Keathley

  • 1Department of Electrical and Computer Engineering, University of Kentucky, Lexington, KY 40506, USA. hastings@engr.uky.edu

Optics Express
|June 25, 2009
PubMed
Summary

Dual-mode surface-plasmon resonance (SPR) sensors effectively distinguish binding events from bulk interference. Optimized designs achieve competitive sensitivity and low limits of detection (LOD), enhancing biosensing capabilities.

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Area of Science:

  • Analytical Chemistry
  • Biophysics
  • Materials Science

Background:

  • Surface-plasmon resonance (SPR) is a label-free optical sensing technique.
  • Distinguishing specific binding from bulk refractive index changes is crucial for accurate SPR measurements.
  • Dual-mode SPR sensors utilize both long-range and short-range surface plasmon waves to address this challenge.

Purpose of the Study:

  • To optimize the design of dual-mode SPR sensors for minimal surface limit of detection (LOD).
  • To evaluate the performance trade-offs between different design parameters for dual-mode SPR sensors.
  • To experimentally validate the performance of optimized dual-mode SPR sensors.

Main Methods:

  • Utilized Cramer-Rao lower bound for spectral shift estimation to optimize sensor design.

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  • Investigated the impact of design parameters on resonance width, minimum reflectivity, and sensitivity for both SPR modes.
  • Employed biotin-streptavidin binding as a model system for experimental verification.

    • Main Results:

    • Achieved near-optimal performance across a range of design parameters despite inherent trade-offs.
    • Demonstrated that dual-mode SPR sensors maintain competitive sensitivity and LOD compared to single-mode sensors.
    • Confirmed the ability of dual-mode SPR sensors to compensate for interfering bulk effects.

    Conclusions:

    • Optimized dual-mode SPR sensor designs offer enhanced performance for detecting surface binding interactions.
    • Dual-mode SPR technology provides a robust solution for accurate biosensing by mitigating bulk effects.
    • The developed sensor design is competitive with existing single-mode SPR sensors while offering superior interference compensation.