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Circulating p53 and cytochrome c levels in acute myocardial infarction patients
Yildiz Dincer1, Solen Himmetoglu, Evin Bozcali
1Department of Biochemistry, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey. stare63@yahoo.com
Background:
Apoptosis causes myocardiocyte loss during and after myocardial infarction. Therapeutic approaches designed to arrest apoptosis would be a significant new development in the recovery of acute myocardial infarction (AMI). In order to examine apoptotic markers in the circulation, serum levels of p53 and cytochrome c were assessed in patients with AMI.
Methods:
Blood samples were taken on admission (before initiation of therapy) and on the 3rd and 7th days of hospitalization. Serum levels of p53 and cytochrome c were measured by enzyme-linked immunassay.
Results:
The serum level of p53 was higher in AMI patients on admission compared to the control group. A time-dependent decrease was observed in the serum level of p53, but there was no significant change in the serum level of cytochrome c during therapy.
Conclusions:
p53, but not cytochrome c, appears to have potential as a biomarker for reporting on apoptosis following myocardial infarction.
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