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Updated: Jun 22, 2026

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
Published on: April 27, 2014
Bladder pain syndrome/interstitial cystitis: a sense of urgency
Philip M Hanno1, Chris R Chapple, Linda D Cardozo
1Hospital of the University of Pennsylvania, University of Pennsylvania, 9 Penn Tower, 3400 Spruce Street, Philadelphia, PA 19104, USA. phil.hanno@uphs.edu
Abstract:
A classic triad of symptoms (bladder pain, urinary frequency, and urgency) has served to define bladder pain syndrome/painful bladder syndrome/interstitial cystitis (BPS/PBS/IC) syndrome. BPS/PBS/IC is a distinct condition and it is likely that the urgency experienced by these patients differs from that experienced by those with overactive bladder syndrome. It is unclear how best to define urgency in the BPS/PBS/IC setting. Differences in the other primary symptoms associated with these conditions probably influence how urgency is perceived. Advances in research into the pathophysiology of urgency and underlying disease processes will help to optimize both the diagnosis and treatment of BPS/PBS/IC.
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