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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
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Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal...
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Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
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Decrease in two intestinal copper/zinc containing proteins with antioxidant function in inflammatory bowel disease.

T P Mulder1, H W Verspaget, A R Janssens

  • 1Department of Gastroenterology and Hepatology, University Hospital, Leiden, The Netherlands.

Gut
|October 1, 1991
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Summary
This summary is machine-generated.

Patients with inflammatory bowel disease show reduced levels of superoxide dismutase and metallothionein, key proteins for scavenging harmful oxygen radicals. This decrease in antioxidant protection may contribute to the disease

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Area of Science:

  • Gastroenterology
  • Biochemistry
  • Oxidative Stress Research

Background:

  • Oxygen-derived radicals are implicated in tissue damage in inflammatory bowel disease (IBD).
  • Endogenous proteins like superoxide dismutase (SOD) and metallothionein (MT) play crucial roles in scavenging these radicals.
  • Copper and zinc are essential cofactors for SOD and MT, respectively.

Purpose of the Study:

  • To quantify the levels of SOD and MT in intestinal tissues of IBD patients.
  • To compare these levels with those in non-inflamed controls.
  • To investigate the potential role of reduced antioxidant capacity in IBD pathogenesis.

Main Methods:

  • Intestinal resection specimens were analyzed from 29 Crohn's disease patients, 12 ulcerative colitis patients, and 18 control subjects.
  • Superoxide dismutase (SOD) and metallothionein (MT) content were measured in tissue samples.
  • Protein concentrations were compared between inflamed and non-inflamed IBD mucosa and control mucosa.

Main Results:

  • SOD levels were significantly lower in inflamed IBD mucosa compared to non-inflamed IBD mucosa.
  • MT levels were decreased in both non-inflamed and inflamed IBD mucosa compared to control mucosa.
  • No significant differences were observed between Crohn's disease and ulcerative colitis, nor were effects of medication or tissue location noted.

Conclusions:

  • IBD patients exhibit diminished levels of SOD and MT in intestinal tissues.
  • This reduction in endogenous antioxidant proteins suggests impaired protection against oxygen-derived radicals in IBD.
  • The findings support a potential contribution of oxidative stress to the pathogenesis of inflammatory bowel disease.