Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ifosfamide-induced neurotoxicity.

J P Curtin1, P P Koonings, M Gutierrez

  • 1Department of Obstetrics and Gynecology, Women's Hospital, Los Angeles, California 90033.

Gynecologic Oncology
|September 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A phase 2 feasibility study of nab-paclitaxel and carboplatin in epithelial carcinoma of the uterus.

Gynecologic oncology·2024
Same author

The effects of melatonin prophylaxis on sensory recovery and postoperative pain following orthognathic surgery: a triple-blind randomized controlled trial and biochemical analysis.

International journal of oral and maxillofacial surgery·2019
Same author

Utility of risk-weighted surgical-pathological factors in early-stage cervical cancer.

British journal of cancer·2013
Same author

Management of recurrent cervical cancer: a review of the literature.

Surgical oncology·2012
Same author

New classification system of radical hysterectomy: emphasis on a three-dimensional anatomic template for parametrial resection.

Gynecologic oncology·2011
Same author

Metastatic and recurrent adenocarcinoma of the uterine cervix: a long-term survival of 16 years.

European journal of gynaecological oncology·2010

Ifosfamide chemotherapy can cause severe neurotoxicity in gynecologic cancer patients. Low serum albumin levels significantly increase the risk of this dangerous side effect.

Area of Science:

  • Oncology
  • Pharmacology
  • Neuroscience

Background:

  • Ifosfamide is a chemotherapy drug used for gynecologic tumors.
  • Neurotoxicity is a known but poorly understood side effect of ifosfamide treatment.

Purpose of the Study:

  • To describe the clinical presentation and risk factors for ifosfamide-induced neurotoxicity.
  • To investigate the association between serum albumin levels and neurotoxicity.

Main Methods:

  • Retrospective analysis of 23 patients treated with ifosfamide.
  • Monitoring for neurotoxicity and recording clinical presentation and outcomes.
  • Correlation of neurotoxicity with serum albumin levels.

Main Results:

  • 26% of patients experienced grade 4 neurotoxicity, including confusion, aphasia, hallucinations, and coma.

Related Experiment Videos

  • Neurotoxicity onset occurred by the end of 24-hr infusions.
  • Low serum albumin (<3.5 g/dl) was significantly associated with severe neurotoxicity (P < 0.001).

    • Conclusions:

    • Ifosfamide can cause severe, potentially fatal neurotoxicity in gynecologic cancer patients.
    • Low serum albumin is a critical risk factor for ifosfamide-induced neurotoxicity.
    • Monitoring serum albumin may help identify patients at high risk for neurotoxicity.