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Adenovirus type 3 outbreak in connecticut associated with a novel variant

Marie L Landry1, Mark G Lebeck, Ana W Capuano

  • 1Department of Laboratory Medicine, Yale New Haven Hospital, Yale University School of Medicine, Connecticut 06520-8035, USA. marie.landry@yale.edu

Journal of Medical Virology
|June 25, 2009
PubMed

Insights

An adenovirus outbreak in Connecticut was linked to a new strain, Ad3a51. This novel adenovirus type caused increased infections, with young children facing severe illness risks.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Adenovirus infections can cause respiratory illness.
  • Adenovirus type 3 (Ad3) is a common cause of conjunctivitis and pharyngitis.

Purpose of the Study:

  • To characterize the adenovirus outbreak in New Haven, Connecticut during 2006-2007.
  • To identify the specific adenovirus strain responsible for the outbreak.

Main Methods:

  • Molecular typing of adenovirus isolates.
  • Restriction enzyme analysis (REA) to differentiate strains.

Main Results:

  • A twofold increase in adenovirus type 3 infections was observed.
  • A novel strain, designated Ad3a51, was identified as the predominant cause of the outbreak.
  • This marked the first detection of Ad3a51 in the United States.
  • Most infections were mild, but severe disease occurred in children under 3.

Conclusions:

  • The 2006-2007 New Haven adenovirus outbreak was primarily caused by the novel Ad3a51 strain.
  • Ad3a51 poses a risk for severe disease in young children.
  • Continued surveillance for novel adenovirus strains is crucial.

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