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Overcoming matrix effects in liquid chromatography-mass spectrometry

Achille Cappiello1, Giorgio Famiglini, Pierangela Palma

  • 1University of Urbino "Carlo Bo", Istituto di Scienze Chimiche "F. Bruner", 61029 Urbino, Italy. achille.cappiello@uniurb.it

Analytical Chemistry
|June 25, 2009
PubMed
Summary

Direct electron ionization liquid chromatography-mass spectrometry (direct-EI LC-MS) overcomes matrix effects common in electrospray ionization mass spectrometry (ESI-MS). This method improves quantitative analysis accuracy and reproducibility in environmental and biological samples.

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