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Development and evaluation of ocular drug delivery system
Ashish Prakash Gorle1, S G Gattani
1Department of Pharmaceutics, RC Patel Institute of Pharmaceutical Education and Research, Shirpur, India. ashishgorle@rediffmail.com
Pharmaceutical Development and Technology
|June 26, 2009
Summary
New ocular inserts using chitosan and gelatin offer improved levofloxacin delivery for conjunctivitis treatment. These stable inserts provide sustained drug release over 24 hours, enhancing therapeutic efficacy.
Area of Science:
- Ophthalmology
- Pharmaceutics
- Materials Science
Background:
- Ocular drug delivery faces challenges in achieving sustained therapeutic levels.
- Conjunctivitis treatment often requires frequent dosing, impacting patient compliance.
- Chitosan and gelatin offer biocompatible matrices for ocular insert development.
Purpose of the Study:
- To develop and evaluate ocular inserts of levofloxacin using chitosan and gelatin.
- To enhance the therapeutic efficacy for conjunctivitis treatment.
- To establish in vitro-in vivo correlation for optimized drug release.
Main Methods:
- Solvent casting technique was employed for ocular insert preparation.
- Evaluation included physical parameters, drug content uniformity, and moisture analysis.
- In vitro drug release studies utilized a flow-through apparatus simulating ocular conditions.
- In vivo studies and stability assessments were performed on optimized formulations.
Main Results:
- Optimized ocular inserts demonstrated zero-order drug release kinetics.
- A strong positive correlation was established between in vitro and in vivo studies.
- The formulations remained stable and intact under ambient conditions for 24 hours.
- Polyethylene glycol (PEG) as a plasticizer significantly influenced drug release profiles.
Conclusions:
- Chitosan-gelatin ocular inserts are a viable alternative for sustained levofloxacin delivery.
- These inserts offer prolonged drug release, improving conjunctivitis treatment efficacy.
- The developed formulations are stable and suitable for extended use.
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