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Chronic venous insufficiency is associated with elevated level of circulating microparticles
A Georgescu1, N Alexandru, D Popov
1Institute of Cellular Biology and Pathology, 'Nicolae Simionescu', Bucharest, Romania. adriana.georgescu@icbp.ro
Journal of Thrombosis and Haemostasis : JTH
|June 26, 2009
Summary
Chronic venous insufficiency (CVI) involves elevated levels of endothelial (EMPs) and platelet microparticles (PMPs), which contribute to vein wall dysfunction. These microparticles play a key role in the altered venous response seen in CVI patients.
Area of Science:
- Vascular Biology
- Cellular Biology
- Biomedical Science
Background:
- Chronic venous insufficiency (CVI) impairs effective blood return from the legs to the heart.
- Microparticles (MPs) are vesicles released by activated or apoptotic vascular and circulating cells.
Purpose of the Study:
- To evaluate circulating endothelial microparticles (EMPs) and platelet microparticles (PMPs) in CVI patients.
- To determine the role of EMPs and PMPs in human peripheral venule dysfunction.
Main Methods:
- Explantation of human peripheral venules from CVI patients and controls.
- Blood sample collection and isolation of circulating MPs.
- Utilized flow cytometry, microscopy, myography, and western blotting.
Main Results:
- CVI patients exhibited elevated circulating EMPs and PMPs compared to controls.
- Observed structural venous wall modifications and altered reactivity associated with MP adherence.
- Demonstrated impaired contractile and relaxation responses in CVI venules, with increased TF and P-Selectin expression.
Conclusions:
- CVI is characterized by increased release of EMPs and PMPs.
- These microparticles significantly contribute to the altered and dysfunctional venous wall response in CVI.
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