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En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries
Published on: February 25, 2016
Nitric oxide production in acute gastroenteritis in Indian children
Thuppal Varadachari Sowmyanarayanan1, Sathish Kumar Natarajan, Anup Ramachandran
1Department of Gastrointestinal Sciences, Christian Medical College, Tamil Nadu, India.
Abstract:
This study compared nitric oxide (NO) levels in 110 children with, and 110 children without, infectious gastroenteritis. Post-infection intestinal function was assessed in a subset. At least one pathogen was identified in 47.2% of cases. The most common diarrhoeal pathogens were rotavirus (22.7%) and norovirus genogroup II (11.8%). The levels of NO measured by median urinary nitrite:creatinine ratio were significantly higher in children with diarrhoea [23.6; interquartile range (IQR) 12.3-46.7] than without diarrhoea (7.8; IQR 4.1-13.2), P<0.001. The ratio was not significantly different between diarrhoeal cases with and without pathogens (P=0.148). Six of twelve children tested had intestinal dysfunction.
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